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The Dow Jones Industrial Average fell 1. Higher final doses may be required if Topiramate is being taken alone, up to 500 mg a day. Nifedipine blocks Ca2+ store refilling through a pathway not involving L-type Ca2+ channels in rabbit arteriolar smooth muscle store refilling through a pathway not involving L-type Ca2+ channels in rabbit arteriolar smooth muscleā€¯. Vaginal misoprostol for cervical ripening before operative hysteroscopy in pre-menopausal women: a double-blind, placebo-controlled trial with three dose regimens. Overdosage may result in vomiting, sedation, disturbances in heart rhythm, dizziness, sweating, nausea, tremor, and rarely amnesia, confusion, coma, or convulsions. Efavirenz was approved in 1998 as an antiretroviral drug (ARV) for people with HIV infection.