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GI toxicity, with little or no increase in efficacy <>see Warnings and Precautions ( 5. For purposes of comparisons of the animal exposure to systemic human exposure, the maximum human systemic dose is defined as 1 gram of RENOVA (tretinoin cream) 0. Desvenlafaxine may increase the hypoglycemic activities of Glimepiride. If you have symptoms of these problems, you should go to the emergency room or call 911 right away. Megan Brooks (2014-01-30). Since olanzapine has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that olanzapine therapy does not affect them adversely <see>Patient Counseling Information ( 17.