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Many months of treatment are often required, and the rate of adverse effects is high regardless of dosage. Approach with caution when coadministering additional medications that decrease renal function. Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Expulsion therapy to help pass stones that have moved into the ureter (but not stones resident in the kidney) is, however, supported by recent controlled trials. The metabolism of Loratadine can be decreased when combined with Diltiazem. The change in weight-for-age z-score also demonstrated a similar pattern, but was not statistically significant.
