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I've felt like I might a couple times, but then I don't and the closest I think I've gotten is having a day where I am overly tired, sleep a whopping 10-12 hours and then I am right as rain. This medication should be used only when clearly needed during pregnancy. The serum concentration of Metoprolol can be increased when it is combined with Thiothixene. Laboratorio titular: Allergan, S. For those greater than 50 kg, the dose range is 4 to 32 mg per day. Adults—At first, 600 milligrams (mg) once a day.