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Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerance. Serious skin or allergic reactions, which may include problems with some of your body organs. Sutton, M; Mounsey, AL; Russell, RG (15 July 2012). Do not take more than 3 tablets per day. In the UK, the patent for simvastatin had expired by 2004. Sepracor Pharmaceuticals Inc.