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Keep taking nebivolol as you have been told by your doctor or other health care provider, even if you feel well. HIV treatment regimen. Fluoxetine is metabolized in the liver by isoenzymes of the cytochrome P450 system, including CYP2D6. Some of these medicines need to be stopped for at least 1 week before you can start using EMSAM and for 2 weeks after you stop using EMSAM. The serum concentration of Propafenone can be decreased when it is combined with Phenytoin. Ascher JA, Cole JO, Colin JN et al.